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Assay Detail

CHEMBL906478

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Functional
Vasorelaxant activity against KCl-induced contraction in Wistar rat aorta
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Aorta
Confidence 1 — Organism
Curated By Autocuration

Target

Aorta (CHEMBL613606)
Type TISSUE
Organism Rattus norvegicus

Publication

Vasorelaxant activity of diterpenes from Croton zambesicus and synthetic trachylobanes and their structure-activity relationships.
Baccelli C, Navarro I, Block S, Abad A, Morel N, Quetin-Leclercq J.
J Nat Prod (2007) 70 : 910 -917
PubMed 17547457 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.06 5.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL226152 1 5.46
CHEMBL225918 1 5.33
CHEMBL388792 1 5.24
CHEMBL388791 1 5.20
CHEMBL388630 1 5.04
CHEMBL387729 1 5.01
CHEMBL389065 MARRUBENOL 1 5.00
CHEMBL226314 1 4.91
CHEMBL225866 ISOPIMARANE 1 4.33
CHEMBL375896 1 -
CHEMBL226104 1 -
CHEMBL461825 1 -
CHEMBL1644111 TRANS-PHYTOL 1 -
CHEMBL390551 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL226152 IC50 = 3500.0 nM 5.46
CHEMBL225918 IC50 = 4650.0 nM 5.33
CHEMBL388792 IC50 = 5800.0 nM 5.24
CHEMBL388791 IC50 = 6300.0 nM 5.20
CHEMBL388630 IC50 = 9100.0 nM 5.04
CHEMBL387729 IC50 = 9750.0 nM 5.01
CHEMBL389065 MARRUBENOL IC50 = 10000.0 nM 5.00
CHEMBL226314 IC50 = 12300.0 nM 4.91
CHEMBL225866 ISOPIMARANE IC50 = 46200.0 nM 4.33
CHEMBL375896 IC50 > 80000.0 nM -
CHEMBL226104 IC50 > 80000.0 nM -
CHEMBL461825 IC50 > 80000.0 nM -
CHEMBL1644111 TRANS-PHYTOL IC50 > 80000.0 nM -
CHEMBL390551 IC50 > 80000.0 nM -