Assay Detail
Binding
CHEMBL906597
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant SIRT2 using fluorescent peptide substrate by fluorescent assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.10 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224864 | — | — | 1 | 5.46 |
| CHEMBL228175 | — | — | 1 | 5.26 |
| CHEMBL225797 | — | — | 1 | 5.22 |
| CHEMBL226115 | — | — | 1 | 4.46 |
| CHEMBL226027 | — | — | 1 | - |
| CHEMBL226026 | — | — | 1 | - |
| CHEMBL225971 | — | — | 1 | - |
| CHEMBL225914 | — | — | 1 | - |
| CHEMBL390332 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224864 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL228175 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL225797 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL226115 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL226027 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL226026 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL225971 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL225914 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL390332 | — | IC50 | > | 10000.0 | nM | - |