Assay Detail
Binding
CHEMBL906617
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase assessed as tRNA amino-acylation
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Leucine--tRNA ligase, cytoplasmic (CHEMBL1075253) ↗| Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
Publication
An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.85 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443052 | TAVABOROLE | 4.0 | 1 | 5.68 |
| CHEMBL214011 | — | — | 1 | 4.02 |
| CHEMBL226509 | — | — | 1 | - |
| CHEMBL226398 | — | — | 1 | - |
| CHEMBL344890 | — | — | 1 | - |
| CHEMBL225804 | — | — | 1 | - |
| CHEMBL388368 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443052 | TAVABOROLE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL214011 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL226509 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL226398 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL344890 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL225804 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL388368 | — | IC50 | > | 100000.0 | nM | - |