Compound Detail
CHEMBL344890
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Basic Information
| ChEMBL ID | CHEMBL344890 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LBUNNMJLXWQQBY-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
139.9
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.82
Ki 1 meas. best 5.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL3229 | IC50 | 5.82 | 5.82 | 1500.0 | 1 |
| Beta-lactamase CHEMBL2026 | Ki | 5.19 | 5.19 | 6400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | IC50 | = | 1500.0 | nM | 5.82 | Inhibition of Wistar rat brain FAAH assessed as [3H]arachidonoylethanolamide hyd... | 18983140 |
| Beta-lactamase | Ki | = | 6400.0 | nM | 5.19 | Inhibitory activity against Escherichia coli AmpC beta-lactamase. | 9804697 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20594849 | 10.1016/j.bmcl.2010.06.039 | Unchecked | 2 |
| 9804697 | 10.1021/jm980343w | Beta-lactamase | 1 |
| 17588934 | 10.1126/science.1142189 | Leucine--tRNA ligase, cytoplasmic | 1 |
| 18983140 | 10.1021/jm801051t | Fatty-acid amide hydrolase 1 | 1 |
| 18983140 | 10.1021/jm801051t | Monoglyceride lipase | 1 |
Data from ChEMBL 36 via Core Engine