Assay Detail
Binding
CHEMBL649554
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Inhibitory activity against Escherichia coli AmpC beta-lactamase.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 5.53 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34964 | — | — | 1 | 7.57 |
| CHEMBL109227 | — | — | 1 | 6.70 |
| CHEMBL143399 | — | — | 1 | 6.66 |
| CHEMBL142592 | — | — | 1 | 6.39 |
| CHEMBL334931 | — | — | 1 | 6.30 |
| CHEMBL342173 | — | — | 1 | 6.11 |
| CHEMBL336239 | — | — | 1 | 5.96 |
| CHEMBL140740 | M(DANSYLAMIDOPHENYL)BORONIC ACID | — | 1 | 5.89 |
| CHEMBL140723 | — | — | 1 | 5.85 |
| CHEMBL139713 | — | — | 1 | 5.80 |
| CHEMBL20945 | — | — | 1 | 5.77 |
| CHEMBL141272 | — | — | 1 | 5.60 |
| CHEMBL82324 | — | — | 1 | 5.54 |
| CHEMBL140254 | — | — | 1 | 5.54 |
| CHEMBL143654 | — | — | 1 | 5.52 |
| CHEMBL20866 | — | — | 1 | 5.44 |
| CHEMBL334932 | — | — | 1 | 5.42 |
| CHEMBL140916 | — | — | 1 | 5.41 |
| CHEMBL139928 | — | — | 1 | 5.38 |
| CHEMBL140780 | TOLYL BORONIC ACID | — | 1 | 5.27 |
| CHEMBL140747 | — | — | 1 | 5.23 |
| CHEMBL21427 | — | — | 1 | 5.23 |
| CHEMBL344890 | — | — | 1 | 5.19 |
| CHEMBL140467 | — | — | 1 | 5.16 |
| CHEMBL20852 | — | — | 1 | 5.14 |
| CHEMBL141079 | — | — | 1 | 5.07 |
| CHEMBL21485 | PHENYLBORONIC ACID | — | 1 | 4.98 |
| CHEMBL342460 | — | — | 1 | 4.96 |
| CHEMBL415532 | — | — | 1 | 4.92 |
| CHEMBL143927 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34964 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL109227 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL143399 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL142592 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL334931 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL342173 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL336239 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL140740 | M(DANSYLAMIDOPHENYL)BORONIC ACID | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL140723 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL139713 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL20945 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL141272 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL82324 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL140254 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL143654 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL20866 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL334932 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL140916 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL139928 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL140780 | TOLYL BORONIC ACID | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL140747 | — | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL21427 | — | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL344890 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL140467 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL20852 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL141079 | — | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL21485 | PHENYLBORONIC ACID | Ki | = | 10500.0 | nM | 4.98 |
| CHEMBL342460 | — | Ki | = | 10900.0 | nM | 4.96 |
| CHEMBL415532 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL143927 | — | Ki | = | 15800.0 | nM | 4.80 |
| CHEMBL341722 | — | Ki | = | 22100.0 | nM | 4.66 |
| CHEMBL139725 | — | Ki | = | 25300.0 | nM | 4.60 |
| CHEMBL141313 | — | Ki | = | 53400.0 | nM | 4.27 |
| CHEMBL31962 | BUTYL BORONIC ACID | Ki | > | 100000.0 | nM | - |
| CHEMBL421765 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL81556 | DIPHENYL BORINIC ACID | Ki | > | 100000.0 | nM | - |
| CHEMBL142083 | — | Ki | > | 100000.0 | nM | - |