Compound Detail
CHEMBL109227
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Basic Information
| ChEMBL ID | CHEMBL109227 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SLHKDOGTVUCXKX-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
241.8
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 6.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Beta-lactamase CHEMBL2026 | Ki | 6.7 | 6.7 | 200.0 | 2 |
| Unchecked CHEMBL612545 | Ki | 6.7 | 6.7 | 200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Beta-lactamase | Ki | = | 200.0 | nM | 6.7 | Binding affinity towards AmpC beta-lactamase binding site from Escherichia coli | 12109906 |
| Beta-lactamase | Ki | = | 200.0 | nM | 6.7 | Inhibitory activity against Escherichia coli AmpC beta-lactamase. | 9804697 |
| Unchecked | Ki | = | 200.0 | nM | 6.7 | Inhibition of AmpC beta lactamase by spectrophotometry | 20452208 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19731939 | 10.1021/jm9009718 | Penicillin-binding protein 2X | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 12109906 | 10.1021/jm020002p | Beta-lactamase | 1 |
| 9804697 | 10.1021/jm980343w | Beta-lactamase | 1 |
| 19731939 | 10.1021/jm9009718 | No relevant target | 1 |
| 20452208 | 10.1016/j.bmcl.2010.04.007 | Unchecked | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine