Assay Detail
Binding
CHEMBL649553
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Binding affinity towards AmpC beta-lactamase binding site from Escherichia coli
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Structure-based approach for binding site identification on AmpC beta-lactamase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.56 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2068465 | — | — | 1 | 7.70 |
| CHEMBL34964 | — | — | 1 | 7.57 |
| CHEMBL113381 | — | — | 1 | 7.10 |
| CHEMBL324688 | — | — | 1 | 6.82 |
| CHEMBL109227 | — | — | 1 | 6.70 |
| CHEMBL320049 | — | — | 1 | 6.50 |
| CHEMBL20945 | — | — | 1 | 5.77 |
| CHEMBL82324 | — | — | 1 | 5.54 |
| CHEMBL139928 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2068465 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL34964 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL113381 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL324688 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL109227 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL320049 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL20945 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL82324 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL139928 | — | Ki | = | 4200.0 | nM | 5.38 |