Compound Detail
CHEMBL82324
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Basic Information
| ChEMBL ID | CHEMBL82324 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SIAVMDKGVRXFAX-UHFFFAOYSA-N |
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
15
Publications
0
Known Names
Molecular Properties
165.9
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 6 meas. best 5.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Beta-lactamase CHEMBL2026 | Ki | 5.54 | 5.54 | 2900.0 | 2 |
| Unchecked CHEMBL612545 | Ki | 5.54 | 5.54 | 2900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Beta-lactamase | Ki | = | 2900.0 | nM | 5.54 | Binding affinity towards AmpC beta-lactamase binding site from Escherichia coli | 12109906 |
| Beta-lactamase | Ki | = | 2900.0 | nM | 5.54 | Inhibitory activity against Escherichia coli AmpC beta-lactamase. | 9804697 |
| Unchecked | Ki | = | 2900.0 | nM | 5.54 | Inhibition of AmpC beta lactamase by spectrophotometry | 20452208 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/0960-894X(96)00466-0 | Subtilisin BL | 3 |
| 24499135 | 10.1021/jm401808n | Staphylococcus aureus | 3 |
| 19731939 | 10.1021/jm9009718 | Penicillin-binding protein 2x | 2 |
| 33223262 | 10.1016/j.ejmech.2020.113002 | Escherichia coli | 2 |
| 33223262 | 10.1016/j.ejmech.2020.113002 | Enterococcus faecium | 2 |
| 33223262 | 10.1016/j.ejmech.2020.113002 | Staphylococcus aureus | 2 |
| 12109906 | 10.1021/jm020002p | Beta-lactamase | 1 |
| - | 10.1016/0960-894X(96)00466-0 | Subtilisin Carlsberg | 1 |
| 9804697 | 10.1021/jm980343w | Beta-lactamase | 1 |
| 19731939 | 10.1021/jm9009718 | D-alanyl-D-alanine carboxypeptidase | 1 |
| 19822427 | 10.1016/j.bmcl.2009.09.077 | Succinyl-diaminopimelate desuccinylase | 1 |
| 20452208 | 10.1016/j.bmcl.2010.04.007 | Unchecked | 1 |
| 24499135 | 10.1021/jm401808n | Quinolone resistance protein NorA | 1 |
| 33223262 | 10.1016/j.ejmech.2020.113002 | Enterococcus faecalis | 1 |
| 33223262 | 10.1016/j.ejmech.2020.113002 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine