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Assay Detail

CHEMBL1120317

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of AmpC beta lactamase by spectrophotometry
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Structural study of phenyl boronic acid derivatives as AmpC beta-lactamase inhibitors.
Tondi D, Calò S, Shoichet BK, Costi MP.
Bioorg Med Chem Lett (2010) 20 : 3416 -3419
PubMed 20452208 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.47 7.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1083472 1 7.64
CHEMBL1084081 1 7.58
CHEMBL1085119 1 7.22
CHEMBL1083147 1 7.08
CHEMBL1086084 1 7.00
CHEMBL1083471 1 7.00
CHEMBL109227 1 6.70
CHEMBL1084082 1 6.46
CHEMBL1085118 1 6.35
CHEMBL20945 1 5.77
CHEMBL1082936 1 5.75
CHEMBL82324 1 5.54
CHEMBL139928 1 5.38
CHEMBL20852 1 5.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1083472 Ki = 23.0 nM 7.64
CHEMBL1084081 Ki = 26.0 nM 7.58
CHEMBL1085119 Ki = 60.0 nM 7.22
CHEMBL1083147 Ki = 83.0 nM 7.08
CHEMBL1086084 Ki = 100.0 nM 7.00
CHEMBL1083471 Ki = 100.0 nM 7.00
CHEMBL109227 Ki = 200.0 nM 6.70
CHEMBL1084082 Ki = 350.0 nM 6.46
CHEMBL1085118 Ki = 450.0 nM 6.35
CHEMBL20945 Ki = 1700.0 nM 5.77
CHEMBL1082936 Ki = 1800.0 nM 5.75
CHEMBL82324 Ki = 2900.0 nM 5.54
CHEMBL139928 Ki = 4200.0 nM 5.38
CHEMBL20852 Ki = 7300.0 nM 5.14