Compound Detail
CHEMBL81556
DIPHENYL BORINIC ACID Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL81556 |
| Name | DIPHENYL BORINIC ACID |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VIGVRXYWWFPORY-UHFFFAOYSA-N |
4
Targets
7
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
182.0
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.06
Ki 3 meas. best 4.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| ORAI 1/2/3 CHEMBL3038476 | IC50 | 5.06 | 5.035 | 8700.0 | 2 |
| Transient receptor potential cation channel subfamily V member 6 CHEMBL1628465 | IC50 | 4.72 | 4.61 | 19100.0 | 2 |
| Chymotrypsinogen A CHEMBL3314 | Ki | 4.7 | 4.7 | 20000.0 | 1 |
| Proprotein convertase subtilisin/kexin type 9 CHEMBL2929 | Ki | 4.52 | 4.52 | 30000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| ORAI 1/2/3 | IC50 | = | 8700.0 | nM | 5.06 | Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Cd2+ influx af... | 23602525 |
| ORAI 1/2/3 | IC50 | = | 9800.0 | nM | 5.01 | Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Ca2+ influx af... | 23602525 |
| Transient receptor potential cation channel subfamily V member 6 | IC50 | = | 19100.0 | nM | 4.72 | Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of ... | 23602525 |
| Chymotrypsinogen A | Ki | = | 20000.0 | nM | 4.7 | Compound was tested for the inhibition of chymotrypsin | - |
| Proprotein convertase subtilisin/kexin type 9 | Ki | = | 30000.0 | nM | 4.52 | Compound was tested for the inhibition of subtilisin | - |
| Transient receptor potential cation channel subfamily V member 6 | IC50 | = | 31500.0 | nM | 4.5 | Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of ... | 23602525 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(01)80401-7 | No relevant target | 2 |
| 23602525 | 10.1016/j.bmc.2013.03.037 | ORAI 1/2/3 | 2 |
| 23602525 | 10.1016/j.bmc.2013.03.037 | Transient receptor potential cation channel subfamily V member 6 | 2 |
| - | 10.1016/S0960-894X(01)80401-7 | Chymotrypsinogen A | 1 |
| - | 10.1016/S0960-894X(01)80401-7 | Proprotein convertase subtilisin/kexin type 9 | 1 |
| - | 10.1016/S0960-894X(01)80401-7 | Serine protease 1 | 1 |
| 9804697 | 10.1021/jm980343w | Beta-lactamase | 1 |
Data from ChEMBL 36 via Core Engine