Assay Detail
Binding
CHEMBL906677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of glu-tagged PI3K C2-beta expressed in SF9/Baculovirus system by SPA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (CHEMBL5554) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.84 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL538346 | — | — | 1 | 8.00 |
| CHEMBL556399 | — | — | 1 | 7.00 |
| CHEMBL541643 | — | — | 1 | 6.66 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL538346 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL556399 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL541643 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL98350 | LY-294002 | IC50 | = | 2100.0 | nM | 5.68 |