Assay Detail
Binding
CHEMBL906816
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Inhibition of human BChE by Ellman's method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.21 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.52 |
| CHEMBL228360 | — | — | 1 | 6.60 |
| CHEMBL229105 | — | — | 1 | 6.25 |
| CHEMBL228361 | — | — | 1 | 6.11 |
| CHEMBL389049 | — | — | 1 | 5.87 |
| CHEMBL228359 | — | — | 1 | 5.80 |
| CHEMBL228950 | — | — | 1 | 5.72 |
| CHEMBL389048 | — | — | 1 | 5.45 |
| CHEMBL228301 | — | — | 1 | 5.28 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.00 |
| CHEMBL228303 | — | — | 1 | 4.97 |
| CHEMBL389047 | — | — | 1 | 4.87 |
| CHEMBL228302 | — | — | 1 | 4.82 |
| CHEMBL426915 | — | — | 1 | 4.80 |
| CHEMBL229001 | — | — | 1 | 4.65 |
| CHEMBL229051 | — | — | 1 | 4.63 |
| CHEMBL390809 | — | — | 1 | 4.57 |
| CHEMBL228999 | — | — | 1 | 4.50 |
| CHEMBL229104 | — | — | 1 | 4.50 |
| CHEMBL229000 | — | — | 1 | 4.42 |
| CHEMBL229052 | — | — | 1 | 4.24 |
| CHEMBL229050 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL228360 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL229105 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL228361 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL389049 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL228359 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL228950 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL389048 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL228301 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 10050.0 | nM | 5.00 |
| CHEMBL228303 | — | IC50 | = | 10790.0 | nM | 4.97 |
| CHEMBL389047 | — | IC50 | = | 13650.0 | nM | 4.87 |
| CHEMBL228302 | — | IC50 | = | 15230.0 | nM | 4.82 |
| CHEMBL426915 | — | IC50 | = | 15670.0 | nM | 4.80 |
| CHEMBL229001 | — | IC50 | = | 22190.0 | nM | 4.65 |
| CHEMBL229051 | — | IC50 | = | 23210.0 | nM | 4.63 |
| CHEMBL390809 | — | IC50 | = | 26830.0 | nM | 4.57 |
| CHEMBL228999 | — | IC50 | = | 31550.0 | nM | 4.50 |
| CHEMBL229104 | — | IC50 | = | 31550.0 | nM | 4.50 |
| CHEMBL229000 | — | IC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL229052 | — | IC50 | = | 57870.0 | nM | 4.24 |
| CHEMBL229050 | — | IC50 | = | 78920.0 | nM | 4.10 |