Assay Detail
Binding
CHEMBL906920
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Displacement of radiolabeled iodo-MCH from human MCHR1 expressed in HEK293 cells
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): discovery of antagonist SB-568849.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 7.13 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441855 | — | — | 1 | 7.80 |
| CHEMBL212890 | — | — | 1 | 7.70 |
| CHEMBL425263 | — | — | 1 | 7.70 |
| CHEMBL2110360 | — | — | 1 | 7.70 |
| CHEMBL214417 | — | — | 1 | 7.60 |
| CHEMBL212032 | — | — | 1 | 7.60 |
| CHEMBL213255 | — | — | 1 | 7.50 |
| CHEMBL214968 | — | — | 1 | 7.50 |
| CHEMBL214715 | — | — | 1 | 7.50 |
| CHEMBL385254 | — | — | 1 | 7.50 |
| CHEMBL213767 | — | — | 1 | 7.40 |
| CHEMBL213370 | — | — | 1 | 7.40 |
| CHEMBL184037 | — | — | 1 | 7.40 |
| CHEMBL214494 | — | — | 1 | 7.30 |
| CHEMBL215493 | — | — | 1 | 7.30 |
| CHEMBL438966 | — | — | 1 | 7.30 |
| CHEMBL213386 | — | — | 1 | 7.20 |
| CHEMBL426147 | — | — | 1 | 7.20 |
| CHEMBL385253 | — | — | 1 | 7.10 |
| CHEMBL213922 | — | — | 1 | 7.10 |
| CHEMBL386600 | — | — | 1 | 7.10 |
| CHEMBL213198 | — | — | 1 | 7.00 |
| CHEMBL212344 | — | — | 1 | 6.90 |
| CHEMBL377658 | — | — | 1 | 6.80 |
| CHEMBL213923 | — | — | 1 | 6.80 |
| CHEMBL215141 | — | — | 1 | 6.70 |
| CHEMBL215898 | — | — | 1 | 6.60 |
| CHEMBL386111 | — | — | 1 | 6.60 |
| CHEMBL214577 | — | — | 1 | 6.60 |
| CHEMBL213171 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441855 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL212890 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL2110360 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL425263 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL214417 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL212032 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL213255 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL214968 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL214715 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL385254 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL213370 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL184037 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL213767 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL438966 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL215493 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL214494 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL213386 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL426147 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL386600 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL213922 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL385253 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL213198 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL212344 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL377658 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL213923 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL215141 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL215898 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL386111 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL214577 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL213171 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL214527 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL214584 | — | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL213363 | — | Ki | < | 6309.57 | nM | - |
| CHEMBL214441 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL386075 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL214482 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL215041 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL386321 | — | Ki | < | 10000.0 | nM | - |