Assay Detail
Functional
CHEMBL906990
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Antagonist activity against FXR assessed as transactivation of luciferase reporter gene in CV1 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.60 | 5.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373765 | — | — | 1 | 5.09 |
| CHEMBL410683 | GUGGULSTERONE | — | 1 | 5.00 |
| CHEMBL218308 | — | — | 1 | 4.61 |
| CHEMBL216782 | — | — | 1 | 4.60 |
| CHEMBL219377 | — | — | 1 | 4.19 |
| CHEMBL413656 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373765 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL410683 | GUGGULSTERONE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL218308 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL216782 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL219377 | — | IC50 | = | 64500.0 | nM | 4.19 |
| CHEMBL413656 | — | IC50 | = | 81100.0 | nM | 4.09 |