Assay Detail
Binding
CHEMBL907133
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Inhibition of human cloned CA1 by CO2 hydration method
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing".
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 5.74 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216319 | — | — | 1 | 8.11 |
| CHEMBL216312 | — | — | 1 | 8.02 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 7.82 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.51 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.11 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.05 |
| CHEMBL216210 | — | — | 1 | 5.92 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 5.92 |
| CHEMBL385152 | — | — | 1 | 5.70 |
| CHEMBL383897 | — | — | 1 | 5.64 |
| CHEMBL217683 | — | — | 1 | 5.62 |
| CHEMBL386318 | — | — | 1 | 5.62 |
| CHEMBL217166 | — | — | 1 | 5.57 |
| CHEMBL216245 | — | — | 1 | 5.51 |
| CHEMBL217454 | — | — | 1 | 5.47 |
| CHEMBL217288 | — | — | 1 | 5.46 |
| CHEMBL216208 | — | — | 1 | 5.44 |
| CHEMBL215156 | — | — | 1 | 5.41 |
| CHEMBL217569 | — | — | 1 | 5.40 |
| CHEMBL425274 | — | — | 1 | 5.36 |
| CHEMBL217303 | — | — | 1 | 5.32 |
| CHEMBL217359 | — | — | 1 | 5.31 |
| CHEMBL215182 | — | — | 1 | 5.29 |
| CHEMBL216214 | — | — | 1 | 5.27 |
| CHEMBL387076 | — | — | 1 | 5.25 |
| CHEMBL214926 | — | — | 1 | 5.24 |
| CHEMBL216563 | — | — | 1 | 5.24 |
| CHEMBL386542 | — | — | 1 | 5.21 |
| CHEMBL386416 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216319 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL216312 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL77517 | INDISULAM | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL216210 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL385152 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL383897 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL217683 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL386318 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL217166 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL216245 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL217454 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL217288 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL216208 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL215156 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL217569 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL425274 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL217303 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL217359 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL215182 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL216214 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL387076 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL216563 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL214926 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL386542 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL386416 | — | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL386266 | — | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL217232 | — | Ki | = | 9100.0 | nM | 5.04 |
| CHEMBL215105 | — | Ki | = | 9200.0 | nM | 5.04 |
| CHEMBL410510 | — | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL384644 | — | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL217304 | — | Ki | = | 10400.0 | nM | 4.98 |