Assay Detail
Binding
CHEMBL907181
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from mu opioid receptor in guinea pig brain homogenate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effects of changes to the chain linking of the C14-amino group to the aryl ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 9.62 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267027 | — | — | 1 | 10.40 |
| CHEMBL443311 | — | — | 1 | 9.89 |
| CHEMBL217395 | — | — | 1 | 9.62 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 9.40 |
| CHEMBL384497 | — | — | 1 | 9.23 |
| CHEMBL216251 | — | — | 1 | 9.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267027 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL443311 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL217395 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL19019 | NALTREXONE | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL384497 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL216251 | — | Ki | = | 0.7 | nM | 9.15 |