Assay Detail
Binding
CHEMBL907196
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Displacement of [125I]IMPY from beta amyloid protein 40
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.79 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217923 | — | — | 1 | 7.60 |
| CHEMBL216553 | — | — | 1 | 7.44 |
| CHEMBL106509 | DEHYDROZINGERONE | — | 1 | 7.25 |
| CHEMBL387276 | — | — | 1 | 6.63 |
| CHEMBL216864 | — | — | 1 | 6.50 |
| CHEMBL386737 | — | — | 1 | 6.08 |
| CHEMBL216432 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217923 | — | Ki | = | 24.9 | nM | 7.60 |
| CHEMBL216553 | — | Ki | = | 36.6 | nM | 7.44 |
| CHEMBL106509 | DEHYDROZINGERONE | Ki | = | 55.9 | nM | 7.25 |
| CHEMBL387276 | — | Ki | = | 232.7 | nM | 6.63 |
| CHEMBL216864 | — | Ki | = | 316.3 | nM | 6.50 |
| CHEMBL386737 | — | Ki | = | 839.2 | nM | 6.08 |
| CHEMBL216432 | — | Ki | = | 958.1 | nM | 6.02 |