Assay Detail
Functional
CHEMBL907267
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Induction of VEGF in HEK293 cells by ELISA
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.01 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221919 | — | — | 1 | 6.85 |
| CHEMBL218493 | — | — | 1 | 6.38 |
| CHEMBL221971 | — | — | 1 | 6.24 |
| CHEMBL221026 | — | — | 1 | 6.21 |
| CHEMBL218288 | — | — | 1 | 6.20 |
| CHEMBL217943 | — | — | 1 | 6.05 |
| CHEMBL218494 | — | — | 1 | 6.05 |
| CHEMBL218481 | — | — | 1 | 5.72 |
| CHEMBL221027 | — | — | 1 | 5.51 |
| CHEMBL374946 | — | — | 1 | 5.50 |
| CHEMBL387428 | — | — | 1 | 5.39 |
| CHEMBL218482 | — | — | 1 | - |
| CHEMBL221918 | — | — | 1 | - |
| CHEMBL441860 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221919 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL218493 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL221971 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL221026 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL218288 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL217943 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL218494 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL218481 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL221027 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL374946 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL387428 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL218482 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL221918 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL441860 | — | EC50 | > | 100000.0 | nM | - |