Assay Detail
Binding
CHEMBL907396
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Inhibition of human truncated 11beta-HSD1 assessed as inhibition of radiolabeled cortisone to cortisol conversion by SPA
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL4235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Adamantane 11-beta-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.84 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220102 | — | — | 1 | 8.70 |
| CHEMBL222319 | — | — | 1 | 8.30 |
| CHEMBL221159 | — | — | 1 | 8.22 |
| CHEMBL222618 | — | — | 1 | 8.22 |
| CHEMBL374110 | — | — | 1 | 8.22 |
| CHEMBL222511 | — | — | 1 | 8.15 |
| CHEMBL220883 | — | — | 1 | 8.15 |
| CHEMBL223804 | — | — | 1 | 8.10 |
| CHEMBL222670 | — | — | 1 | 8.05 |
| CHEMBL220282 | — | — | 1 | 7.89 |
| CHEMBL376293 | — | — | 1 | 7.89 |
| CHEMBL376695 | — | — | 1 | 7.89 |
| CHEMBL223138 | — | — | 1 | 7.77 |
| CHEMBL219712 | — | — | 1 | 7.75 |
| CHEMBL222365 | — | — | 1 | 7.66 |
| CHEMBL373792 | — | — | 1 | 7.38 |
| CHEMBL223083 | — | — | 1 | 7.14 |
| CHEMBL220153 | — | — | 1 | 6.92 |
| CHEMBL222669 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220102 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL222319 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL221159 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL222618 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL374110 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL222511 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL220883 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL223804 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL222670 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL220282 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL376293 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL376695 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL223138 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL219712 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL222365 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL373792 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL223083 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL220153 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL222669 | — | Ki | = | 250.0 | nM | 6.60 |