Compound Detail
CHEMBL221159
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Basic Information
| ChEMBL ID | CHEMBL221159 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CEZQNMXBDYZVET-VWOQGHHKSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
318.5
MW (Da)
2.06
ALogP
3
HBA
2
HBD
52.6
PSA (Ų)
0.84
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.22
IC50 1 meas. best 6.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 11-beta-hydroxysteroid dehydrogenase 1 CHEMBL4235 | Ki | 8.22 | 8.22 | 6.0 | 1 |
| 11-beta-hydroxysteroid dehydrogenase 1 CHEMBL3910 | Ki | 7.24 | 7.24 | 58.0 | 1 |
| 11-beta-hydroxysteroid dehydrogenase 1 CHEMBL4235 | IC50 | 6.41 | 6.41 | 390.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 11-beta-hydroxysteroid dehydrogenase 1 | Ki | = | 6.0 | nM | 8.22 | Inhibition of human truncated 11beta-HSD1 assessed as inhibition of radiolabeled... | 16996734 |
| 11-beta-hydroxysteroid dehydrogenase 1 | Ki | = | 58.0 | nM | 7.24 | Inhibition of mouse truncated 11beta-HSD1 assessed as inhibition of radiolabeled... | 16996734 |
| 11-beta-hydroxysteroid dehydrogenase 1 | IC50 | = | 390.0 | nM | 6.41 | Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as inhibition... | 16996734 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16996734 | 10.1016/j.bmcl.2006.08.129 | 11-beta-hydroxysteroid dehydrogenase 1 | 3 |
| 16996734 | 10.1016/j.bmcl.2006.08.129 | 11-beta-hydroxysteroid dehydrogenase type 2 | 2 |
| 16996734 | 10.1016/j.bmcl.2006.08.129 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine