Assay Detail
Binding
CHEMBL907397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse truncated 11beta-HSD1 assessed as inhibition of radiolabeled cortisone to cortisol conversion by SPA
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL3910) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Adamantane 11-beta-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.21 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220102 | — | — | 1 | 8.70 |
| CHEMBL222319 | — | — | 1 | 8.52 |
| CHEMBL222511 | — | — | 1 | 8.52 |
| CHEMBL220282 | — | — | 1 | 8.40 |
| CHEMBL222618 | — | — | 1 | 8.30 |
| CHEMBL222670 | — | — | 1 | 8.30 |
| CHEMBL374110 | — | — | 1 | 7.82 |
| CHEMBL223804 | — | — | 1 | 7.82 |
| CHEMBL373792 | — | — | 1 | 7.58 |
| CHEMBL221159 | — | — | 1 | 7.24 |
| CHEMBL376695 | — | — | 1 | 6.75 |
| CHEMBL223138 | — | — | 1 | 6.57 |
| CHEMBL220883 | — | — | 1 | 6.30 |
| CHEMBL222365 | — | — | 1 | 6.24 |
| CHEMBL219712 | — | — | 1 | 6.24 |
| CHEMBL220153 | — | — | 1 | 6.16 |
| CHEMBL223083 | — | — | 1 | 5.92 |
| CHEMBL376293 | — | — | 1 | 5.82 |
| CHEMBL222669 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220102 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL222319 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL222511 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL220282 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL222618 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL222670 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL374110 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL223804 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL373792 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL221159 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL376695 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL223138 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL220883 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL222365 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL219712 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL220153 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL223083 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL376293 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL222669 | — | Ki | = | 1700.0 | nM | 5.77 |