Assay Detail

CHEMBL907450

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Functional

Antiproliferative activity against rat 13762 cell line

ChEMBL ↗

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Target

13762 (CHEMBL613867) ↗

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13762 (CHEMBL613867) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target 13762

CHEMBL613867

Anchored from Assay target.

Protein identity 13762

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Cell Type	13762
Confidence	1 — Organism
Curated By	Expert

Target

13762 (CHEMBL613867) ↗

Type	CELL-LINE
Organism	Rattus norvegicus

Publication

Activity of nitrogen-containing and non-nitrogen-containing bisphosphonates on tumor cell lines.

Zhang Y, Leon A, Song Y, Studer D, Haase C, Koscielski LA, Oldfield E.
J Med Chem (2006) 49 : 5804 -5814
PubMed 16970405 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	4.47	4.47

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL834	PAMIDRONIC ACID	4.0	1	4.47
CHEMBL923	RISEDRONIC ACID	4.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL834	PAMIDRONIC ACID	IC50	=	33600.0	nM	4.47
CHEMBL923	RISEDRONIC ACID	IC50	>	40000.0	nM	-