Assay Detail
Functional
CHEMBL907526
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Inhibition of LPS-induced TNFalpha production in human whole blood
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New modifications to the area of pyrazole-naphthyl urea based p38 MAP kinase inhibitors that bind to the adenine/ATP site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.03 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245584 | — | — | 1 | 7.05 |
| CHEMBL392249 | — | — | 1 | 6.80 |
| CHEMBL392248 | — | — | 1 | 6.70 |
| CHEMBL381743 | — | — | 1 | 6.64 |
| CHEMBL392247 | — | — | 1 | 6.23 |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 6.11 |
| CHEMBL410761 | — | — | 1 | 6.02 |
| CHEMBL394099 | — | — | 1 | 5.96 |
| CHEMBL246377 | — | — | 1 | 5.77 |
| CHEMBL246176 | — | — | 1 | 5.44 |
| CHEMBL394100 | — | — | 1 | 5.41 |
| CHEMBL246280 | — | — | 1 | 5.19 |
| CHEMBL245583 | — | — | 1 | 5.04 |
| CHEMBL393890 | — | — | 1 | - |
| CHEMBL246582 | — | — | 1 | - |
| CHEMBL245386 | — | — | 1 | - |
| CHEMBL420047 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245584 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL392249 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL392248 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL381743 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL392247 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL103667 | DORAMAPIMOD | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL410761 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL394099 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL246377 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL246176 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL394100 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL246280 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL245583 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL393890 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL246582 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL245386 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL420047 | — | IC50 | > | 15000.0 | nM | - |