Assay Detail
Binding
CHEMBL907546
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Inhibition of KDR
34
Total Activities
34
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Thienopyridine urea inhibitors of KDR kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.19 | 8.30 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268826 | — | — | 1 | 8.30 |
| CHEMBL231127 | — | — | 1 | 8.10 |
| CHEMBL427267 | — | — | 1 | 8.05 |
| CHEMBL394619 | — | — | 1 | 8.05 |
| CHEMBL231308 | — | — | 1 | 8.00 |
| CHEMBL398196 | — | — | 1 | 7.96 |
| CHEMBL231612 | — | — | 1 | 7.96 |
| CHEMBL231511 | — | — | 1 | 7.89 |
| CHEMBL231209 | — | — | 1 | 7.82 |
| CHEMBL231309 | — | — | 1 | 7.80 |
| CHEMBL231411 | — | — | 1 | 7.68 |
| CHEMBL394790 | — | — | 1 | 7.66 |
| CHEMBL231356 | — | — | 1 | 7.64 |
| CHEMBL231109 | — | — | 1 | 7.60 |
| CHEMBL231456 | — | — | 1 | 7.58 |
| CHEMBL389524 | — | — | 1 | 7.57 |
| CHEMBL396737 | — | — | 1 | 7.52 |
| CHEMBL231412 | — | — | 1 | 7.42 |
| CHEMBL396494 | — | — | 1 | 7.35 |
| CHEMBL231255 | — | — | 1 | 7.25 |
| CHEMBL231410 | — | — | 1 | 7.12 |
| CHEMBL231357 | — | — | 1 | 7.03 |
| CHEMBL394789 | — | — | 1 | 6.82 |
| CHEMBL231454 | — | — | 1 | 6.60 |
| CHEMBL231128 | — | — | 1 | 6.41 |
| CHEMBL389299 | — | — | 1 | 6.39 |
| CHEMBL231310 | — | — | 1 | 6.38 |
| CHEMBL231415 | — | — | 1 | 6.31 |
| CHEMBL394620 | — | — | 1 | 6.28 |
| CHEMBL231355 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268826 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL231127 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL427267 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL394619 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL231308 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL398196 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL231612 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL231511 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL231209 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL231309 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL231411 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL394790 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL231356 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL231109 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL231456 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL389524 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL396737 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL231412 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL396494 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL231255 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL231410 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL231357 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL394789 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL231454 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL231128 | — | IC50 | = | 388.0 | nM | 6.41 |
| CHEMBL389299 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL231310 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL231415 | — | IC50 | = | 491.0 | nM | 6.31 |
| CHEMBL394620 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL231355 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL231153 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL231254 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL231455 | — | Activity | - | — | - | |
| CHEMBL437375 | — | IC50 | > | 12500.0 | nM | - |