Compound Detail
CHEMBL231456
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL231456 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YAXKDFFAKGXIMN-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
374.5
MW (Da)
5.50
ALogP
4
HBA
3
HBD
80.0
PSA (Ų)
0.44
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.58 | 7.215 | 26.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 26.0 | nM | 7.58 | Inhibition of KDR | 17188869 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 141.0 | nM | 6.85 | Inhibition of human KDR phosphorylation in NIH3T3 cells | 17188869 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17188869 | 10.1016/j.bmcl.2006.12.015 | Vascular endothelial growth factor receptor 2 | 2 |
Data from ChEMBL 36 via Core Engine