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Assay Detail

CHEMBL907635

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Binding
Inhibition of factor 11a
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Coagulation factor XI (CHEMBL2820)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants.
Lin J, Deng H, Jin L, Pandey P, Quinn J, Cantin S, Rynkiewicz MJ, Gorga JC, Bibbins F, Celatka CA, Nagafuji P, Bannister TD, Meyers HV, Babine RE, Hayward NJ, Weaver D, Benjamin H, Stassen F, Abdel-Meguid SS, Strickler JE.
J Med Chem (2006) 49 : 7781 -7791
PubMed 17181160 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 6.79 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL413155 1 8.22
CHEMBL384971 1 8.15
CHEMBL265121 1 8.10
CHEMBL119057 1 8.00
CHEMBL375816 1 8.00
CHEMBL264357 1 7.92
CHEMBL268003 1 7.55
CHEMBL412546 1 7.54
CHEMBL273653 1 7.52
CHEMBL375599 1 7.35
CHEMBL266570 1 7.20
CHEMBL384603 1 7.12
CHEMBL219440 1 7.03
CHEMBL100320 1 6.94
CHEMBL384693 1 6.88
CHEMBL218594 1 6.87
CHEMBL384430 1 6.80
CHEMBL375597 1 6.70
CHEMBL191264 1 6.59
CHEMBL219462 1 6.47
CHEMBL273666 1 6.45
CHEMBL384431 1 6.39
CHEMBL273652 1 6.27
CHEMBL375598 1 6.15
CHEMBL219354 1 6.04
CHEMBL384432 1 5.72
CHEMBL384891 1 5.66
CHEMBL268452 1 5.64
CHEMBL218978 1 5.58
CHEMBL265598 1 5.04

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL413155 IC50 = 6.0 nM 8.22
CHEMBL384971 IC50 = 7.0 nM 8.15
CHEMBL265121 IC50 = 8.0 nM 8.10
CHEMBL119057 IC50 = 10.0 nM 8.00
CHEMBL375816 IC50 = 10.0 nM 8.00
CHEMBL264357 IC50 = 12.0 nM 7.92
CHEMBL268003 IC50 = 28.0 nM 7.55
CHEMBL412546 IC50 = 29.0 nM 7.54
CHEMBL273653 IC50 = 30.0 nM 7.52
CHEMBL375599 IC50 = 45.0 nM 7.35
CHEMBL266570 IC50 = 63.0 nM 7.20
CHEMBL384603 IC50 = 76.0 nM 7.12
CHEMBL219440 IC50 = 93.0 nM 7.03
CHEMBL100320 IC50 = 114.0 nM 6.94
CHEMBL384693 IC50 = 132.0 nM 6.88
CHEMBL218594 IC50 = 136.0 nM 6.87
CHEMBL384430 IC50 = 160.0 nM 6.80
CHEMBL375597 IC50 = 200.0 nM 6.70
CHEMBL191264 IC50 = 258.0 nM 6.59
CHEMBL219462 IC50 = 340.0 nM 6.47
CHEMBL273666 IC50 = 356.0 nM 6.45
CHEMBL384431 IC50 = 403.0 nM 6.39
CHEMBL273652 IC50 = 533.0 nM 6.27
CHEMBL375598 IC50 = 710.0 nM 6.15
CHEMBL219354 IC50 = 920.0 nM 6.04
CHEMBL384432 IC50 = 1920.0 nM 5.72
CHEMBL384891 IC50 = 2200.0 nM 5.66
CHEMBL268452 IC50 = 2300.0 nM 5.64
CHEMBL218978 IC50 = 2600.0 nM 5.58
CHEMBL265598 IC50 = 9200.0 nM 5.04
CHEMBL216110 IC50 = 26000.0 nM 4.58