Assay Detail
Functional
CHEMBL907673
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MCH-mediated calcium release in IMR-32 cells
10
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor (CHEMBL2111437) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Constrained 7-fluorocarboxychromone-4-aminopiperidine based Melanin-concentrating hormone receptor 1 antagonists: the effects of chirality on substituted indan-1-ylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.13 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214585 | — | — | 3 | 7.82 |
| CHEMBL214731 | — | — | 1 | 7.60 |
| CHEMBL215661 | — | — | 3 | 7.58 |
| CHEMBL384919 | — | — | 1 | 7.02 |
| CHEMBL384111 | — | — | 1 | 6.76 |
| CHEMBL425257 | — | — | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214585 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL214731 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL215661 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL214585 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL215661 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL384919 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL384111 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL425257 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL214585 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL215661 | — | IC50 | > | 10000.0 | nM | - |