Assay Detail
Functional
CHEMBL907685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Potassium voltage-gated channel subfamily A member 5 (CHEMBL4306) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and synthesis of tetrahydroindolone-derived carbamates as Kv1.5 blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.76 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216281 | — | — | 1 | 7.68 |
| CHEMBL217347 | — | — | 1 | 7.17 |
| CHEMBL217333 | — | — | 1 | 6.56 |
| CHEMBL217348 | — | — | 1 | 6.46 |
| CHEMBL385237 | — | — | 1 | 6.43 |
| CHEMBL217672 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216281 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL217347 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL217333 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL217348 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL385237 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL217672 | — | IC50 | = | 547.0 | nM | 6.26 |