Compound Detail
CHEMBL217347
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Basic Information
| ChEMBL ID | CHEMBL217347 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NATLTWZVCBHRJN-LTGZKZEYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
311.4
MW (Da)
4.17
ALogP
3
HBA
2
HBD
66.5
PSA (Ų)
0.66
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily A member 5 CHEMBL4306 | IC50 | 7.17 | 7.17 | 67.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily A member 5 | IC50 | = | 67.0 | nM | 7.17 | Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assay | 16942878 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16942878 | 10.1016/j.bmcl.2006.08.059 | Potassium voltage-gated channel subfamily A member 5 | 2 |
| 16942878 | 10.1016/j.bmcl.2006.08.059 | Unchecked | 2 |
| 16942878 | 10.1016/j.bmcl.2006.08.059 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 16942878 | 10.1016/j.bmcl.2006.08.059 | Voltage-gated L-type calcium channel | 1 |
Data from ChEMBL 36 via Core Engine