Assay Detail
Binding
CHEMBL907721
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Displacement of [3H]WIN-35428 from DAT in rat striatal membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2beta-carbomethoxy-3beta-biphenyltropane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.05 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218082 | — | — | 1 | 9.38 |
| CHEMBL214230 | — | — | 1 | 8.30 |
| CHEMBL217627 | — | — | 1 | 7.89 |
| CHEMBL273878 | — | — | 1 | 7.82 |
| CHEMBL385942 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218082 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL214230 | — | Ki | = | 5.03 | nM | 8.30 |
| CHEMBL217627 | — | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL273878 | — | Ki | = | 15.1 | nM | 7.82 |
| CHEMBL385942 | — | Ki | = | 134.0 | nM | 6.87 |