Assay Detail
Functional
CHEMBL907862
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Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as cAMP levels
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent benzimidazolone based human beta(3)-adrenergic receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.15 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434763 | — | — | 1 | 8.28 |
| CHEMBL384560 | — | — | 1 | 8.28 |
| CHEMBL221188 | — | — | 1 | 8.27 |
| CHEMBL386016 | — | — | 1 | 8.15 |
| CHEMBL374867 | — | — | 1 | 8.00 |
| CHEMBL218210 | — | — | 1 | 7.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434763 | — | EC50 | = | 5.2 | nM | 8.28 |
| CHEMBL384560 | — | EC50 | = | 5.2 | nM | 8.28 |
| CHEMBL221188 | — | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL386016 | — | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL374867 | — | EC50 | = | 10.1 | nM | 8.00 |
| CHEMBL218210 | — | EC50 | = | 11.7 | nM | 7.93 |