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Compound Detail

CHEMBL221188

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CC(C)(Cc1ccc(Oc2ccc(C(N)=O)cn2)cc1)NC[C@H](O)COc1cccc2[nH]c(=O)n(CCC3CC3)c12

Basic Information

ChEMBL ID CHEMBL221188
Phase Preclinical
Structure Type MOL
InChI Key FYTAWHRFZVJYPT-QHCPKHFHSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

559.7
MW (Da)
3.77
ALogP
8
HBA
4
HBD
144.5
PSA (Ų)
0.18
QED
1
Ro5 Violations
14
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C31H37N5O5
MW 559.67
Aromatic Rings 4
Heavy Atoms 41
NP-Likeness -0.89

Activity Summary

EC50 2 meas. best 8.27

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 8.27 8.27 5.4 1
Beta-3 adrenergic receptor
CHEMBL4031
EC50 8.17 8.17 6.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16931005 10.1016/j.bmcl.2006.08.010 Beta-3 adrenergic receptor 4
16931005 10.1016/j.bmcl.2006.08.010 Beta-2 adrenergic receptor 2
16931005 10.1016/j.bmcl.2006.08.010 Beta-1 adrenergic receptor 2
16931005 10.1016/j.bmcl.2006.08.010 Rattus norvegicus 1

Data from ChEMBL 36 via Core Engine