Assay Detail
Functional
CHEMBL907877
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Antiproliferative activity against A375 cells
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological study of 4-aminopyrimidine-5-carboxaldehyde oximes as antiproliferative VEGFR-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.51 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221224 | — | — | 1 | 7.68 |
| CHEMBL223892 | — | — | 1 | 7.57 |
| CHEMBL426929 | — | — | 1 | 7.55 |
| CHEMBL219676 | — | — | 1 | 7.52 |
| CHEMBL435748 | — | — | 1 | 7.21 |
| CHEMBL223534 | — | — | 1 | 6.88 |
| CHEMBL219983 | — | — | 1 | 6.63 |
| CHEMBL220951 | — | — | 1 | 6.52 |
| CHEMBL223622 | — | — | 1 | 6.49 |
| CHEMBL219729 | — | — | 1 | 6.49 |
| CHEMBL222076 | — | — | 1 | 6.47 |
| CHEMBL220391 | — | — | 1 | 6.47 |
| CHEMBL223535 | — | — | 1 | 6.46 |
| CHEMBL223486 | — | — | 1 | 6.45 |
| CHEMBL220890 | — | — | 1 | 6.43 |
| CHEMBL373826 | — | — | 1 | 6.35 |
| CHEMBL220988 | — | — | 1 | 6.31 |
| CHEMBL374240 | — | — | 1 | 6.31 |
| CHEMBL222828 | — | — | 1 | 6.30 |
| CHEMBL387313 | — | — | 1 | 6.11 |
| CHEMBL219886 | — | — | 1 | 6.05 |
| CHEMBL220444 | — | — | 1 | 5.80 |
| CHEMBL220523 | — | — | 1 | 5.74 |
| CHEMBL223086 | — | — | 1 | 5.67 |
| CHEMBL219677 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221224 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL223892 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL426929 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL219676 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL435748 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL223534 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL219983 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL220951 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL223622 | — | IC50 | = | 327.0 | nM | 6.49 |
| CHEMBL219729 | — | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL222076 | — | IC50 | = | 336.0 | nM | 6.47 |
| CHEMBL220391 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL223535 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL223486 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL220890 | — | IC50 | = | 372.0 | nM | 6.43 |
| CHEMBL373826 | — | IC50 | = | 446.0 | nM | 6.35 |
| CHEMBL220988 | — | IC50 | = | 492.0 | nM | 6.31 |
| CHEMBL374240 | — | IC50 | = | 492.0 | nM | 6.31 |
| CHEMBL222828 | — | IC50 | = | 501.0 | nM | 6.30 |
| CHEMBL387313 | — | IC50 | = | 783.0 | nM | 6.11 |
| CHEMBL219886 | — | IC50 | = | 886.0 | nM | 6.05 |
| CHEMBL220444 | — | IC50 | = | 1599.0 | nM | 5.80 |
| CHEMBL220523 | — | IC50 | = | 1825.0 | nM | 5.74 |
| CHEMBL223086 | — | IC50 | = | 2156.0 | nM | 5.67 |
| CHEMBL219677 | — | IC50 | = | 4924.0 | nM | 5.31 |