Assay Detail
Binding
CHEMBL908002
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin polymerization
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Total synthesis and biological evaluation of ustiloxin natural products and two analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.30 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39541 | DOLASTATIN-10 | 2.0 | 1 | 9.30 |
| CHEMBL212074 | USTILOXIN A | — | 1 | 5.96 |
| CHEMBL386110 | USTILOXIN D | — | 1 | 5.82 |
| CHEMBL1791395 | — | — | 1 | 5.32 |
| CHEMBL214706 | USTILOXIN F | — | 1 | 5.09 |
| CHEMBL378835 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39541 | DOLASTATIN-10 | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL212074 | USTILOXIN A | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL386110 | USTILOXIN D | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1791395 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL214706 | USTILOXIN F | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL378835 | — | IC50 | > | 40000.0 | nM | - |