Assay Detail
Binding
CHEMBL908004
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Inhibition of rat testis 17-alpha-hydroxylase component of P450-17alpha
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL4430) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.74 | 5.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386256 | — | — | 1 | 5.53 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 5.42 |
| CHEMBL213493 | — | — | 1 | 5.23 |
| CHEMBL211207 | — | — | 1 | 4.78 |
| CHEMBL214932 | — | — | 1 | 4.56 |
| CHEMBL441367 | — | — | 1 | 4.53 |
| CHEMBL215320 | — | — | 1 | 4.51 |
| CHEMBL380271 | — | — | 1 | 4.51 |
| CHEMBL379290 | — | — | 1 | 4.30 |
| CHEMBL377770 | — | — | 1 | 4.02 |
| CHEMBL14192 | BENZYLIMIDAZOLE | — | 1 | - |
| CHEMBL215425 | — | — | 1 | - |
| CHEMBL385589 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386256 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL213493 | — | IC50 | = | 5850.0 | nM | 5.23 |
| CHEMBL211207 | — | IC50 | = | 16550.0 | nM | 4.78 |
| CHEMBL214932 | — | IC50 | = | 27810.0 | nM | 4.56 |
| CHEMBL441367 | — | IC50 | = | 29840.0 | nM | 4.53 |
| CHEMBL215320 | — | IC50 | = | 30660.0 | nM | 4.51 |
| CHEMBL380271 | — | IC50 | = | 30950.0 | nM | 4.51 |
| CHEMBL379290 | — | IC50 | = | 49640.0 | nM | 4.30 |
| CHEMBL377770 | — | IC50 | = | 96460.0 | nM | 4.02 |
| CHEMBL14192 | BENZYLIMIDAZOLE | IC50 | = | 154200.0 | nM | - |
| CHEMBL215425 | — | IC50 | = | 120200.0 | nM | - |
| CHEMBL385589 | — | IC50 | - | — | - |