Assay Detail
Binding
CHEMBL908006
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Inhibition of rat testis 17,20 lyase component of P450-17alpha
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL4430) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.50 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386256 | — | — | 1 | 6.48 |
| CHEMBL213493 | — | — | 1 | 6.26 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 5.78 |
| CHEMBL214932 | — | — | 1 | 5.71 |
| CHEMBL211207 | — | — | 1 | 5.54 |
| CHEMBL441367 | — | — | 1 | 5.31 |
| CHEMBL380271 | — | — | 1 | 5.21 |
| CHEMBL377770 | — | — | 1 | 4.95 |
| CHEMBL14192 | BENZYLIMIDAZOLE | — | 1 | 4.29 |
| CHEMBL215320 | — | — | 1 | - |
| CHEMBL379290 | — | — | 1 | - |
| CHEMBL215425 | — | — | 1 | - |
| CHEMBL385589 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386256 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL213493 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL214932 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL211207 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL441367 | — | IC50 | = | 4940.0 | nM | 5.31 |
| CHEMBL380271 | — | IC50 | = | 6140.0 | nM | 5.21 |
| CHEMBL377770 | — | IC50 | = | 11260.0 | nM | 4.95 |
| CHEMBL14192 | BENZYLIMIDAZOLE | IC50 | = | 50900.0 | nM | 4.29 |
| CHEMBL215320 | — | IC50 | - | — | - | |
| CHEMBL379290 | — | IC50 | - | — | - | |
| CHEMBL215425 | — | IC50 | - | — | - | |
| CHEMBL385589 | — | IC50 | - | — | - |