Assay Detail
Binding
CHEMBL908007
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Inhibition of CDK1/cyclinB by Flashplate assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B (CHEMBL2094127) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis of 2-amino-4-(7-azaindol-3-yl)pyrimidines as cyclin dependent kinase 1 (CDK1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.51 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL426509 | — | — | 1 | 9.22 |
| CHEMBL384350 | — | — | 1 | 9.22 |
| CHEMBL212552 | — | — | 1 | 9.00 |
| CHEMBL377449 | — | — | 1 | 8.72 |
| CHEMBL212299 | — | — | 1 | 8.70 |
| CHEMBL212491 | — | — | 1 | 8.52 |
| CHEMBL212833 | — | — | 1 | 8.05 |
| CHEMBL380301 | — | — | 1 | 7.89 |
| CHEMBL385478 | — | — | 1 | 7.85 |
| CHEMBL385275 | — | — | 1 | 7.51 |
| CHEMBL383893 | — | — | 1 | 7.40 |
| CHEMBL213023 | — | — | 1 | 7.36 |
| CHEMBL377048 | — | — | 1 | 7.34 |
| CHEMBL378768 | — | — | 1 | 7.27 |
| CHEMBL385827 | — | — | 1 | 7.25 |
| CHEMBL214819 | — | — | 1 | 7.24 |
| CHEMBL213277 | — | — | 1 | 7.17 |
| CHEMBL215048 | — | — | 1 | 6.89 |
| CHEMBL213204 | — | — | 1 | 6.86 |
| CHEMBL213207 | — | — | 1 | 6.82 |
| CHEMBL212908 | — | — | 1 | 6.55 |
| CHEMBL214055 | — | — | 1 | 5.00 |
| CHEMBL212347 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL426509 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL384350 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL212552 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL377449 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL212299 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL212491 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL212833 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL380301 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL385478 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL385275 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL383893 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL213023 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL377048 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL378768 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL385827 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL214819 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL213277 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL215048 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL213204 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL213207 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL212908 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL214055 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL212347 | — | IC50 | = | 10400.0 | nM | 4.98 |