Assay Detail
ADMET
CHEMBL908192
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Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 10 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | OST |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.94 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216998 | — | — | 1 | 7.39 |
| CHEMBL220459 | — | — | 1 | 6.96 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 6.96 |
| CHEMBL103283 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216998 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL220459 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL182 | GANCICLOVIR | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL103283 | — | IC50 | = | 370.0 | nM | 6.43 |