Assay Detail
Binding
CHEMBL908196
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Inhibition of SIRT2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.24 | 4.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL380797 | SIRTINOL | — | 1 | 4.35 |
| CHEMBL425294 | — | — | 1 | 4.25 |
| CHEMBL373990 | — | — | 1 | 4.23 |
| CHEMBL220458 | — | — | 1 | 4.13 |
| CHEMBL220354 | — | — | 1 | - |
| CHEMBL220300 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL380797 | SIRTINOL | IC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL425294 | — | IC50 | = | 56700.0 | nM | 4.25 |
| CHEMBL373990 | — | IC50 | = | 58400.0 | nM | 4.23 |
| CHEMBL220458 | — | IC50 | = | 74300.0 | nM | 4.13 |
| CHEMBL220354 | — | IC50 | = | 137400.0 | nM | - |
| CHEMBL220300 | — | IC50 | = | 195900.0 | nM | - |