Assay Detail
Functional
CHEMBL908225
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Inhibition of HCT116 cell proliferation (mean of two experiments)
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.87 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216896 | — | — | 1 | 7.22 |
| CHEMBL216463 | — | — | 1 | 7.16 |
| CHEMBL441699 | — | — | 1 | 7.16 |
| CHEMBL387447 | — | — | 1 | 7.10 |
| CHEMBL385934 | — | — | 1 | 7.10 |
| CHEMBL217882 | — | — | 1 | 7.05 |
| CHEMBL436964 | — | — | 1 | 7.05 |
| CHEMBL216301 | — | — | 1 | 7.00 |
| CHEMBL216300 | — | — | 1 | 7.00 |
| CHEMBL217615 | — | — | 1 | 6.96 |
| CHEMBL216884 | — | — | 1 | 6.96 |
| CHEMBL217246 | — | — | 1 | 6.92 |
| CHEMBL384733 | — | — | 1 | 6.85 |
| CHEMBL218392 | — | — | 1 | 6.75 |
| CHEMBL385562 | — | — | 1 | 6.75 |
| CHEMBL217716 | — | — | 1 | 6.24 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216896 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL216463 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL441699 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL387447 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL385934 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL217882 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL436964 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL216301 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL216300 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL217615 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL216884 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL217246 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL384733 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL218392 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL385562 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL217716 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2520.0 | nM | 5.60 |