Assay Detail
Functional
CHEMBL908262
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Inhibition of DLD-1 cell proliferation (mean)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.15 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384522 | — | — | 1 | 5.75 |
| CHEMBL368036 | — | — | 1 | 5.64 |
| CHEMBL217338 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384522 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL368036 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL217338 | — | EC50 | = | 86000.0 | nM | 4.07 |