Assay Detail
Functional
CHEMBL908306
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contraction
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.30 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217511 | — | — | 1 | 9.17 |
| CHEMBL215375 | — | — | 1 | 7.72 |
| CHEMBL11458 | — | — | 1 | 7.66 |
| CHEMBL214841 | — | — | 1 | 7.54 |
| CHEMBL11684 | (-)-CROMAKALIM | — | 1 | 7.46 |
| CHEMBL216256 | — | — | 1 | 7.26 |
| CHEMBL2062142 | — | — | 1 | 6.99 |
| CHEMBL424909 | — | — | 1 | 6.89 |
| CHEMBL387063 | — | — | 1 | 6.61 |
| CHEMBL18861 | ZD-6169 | — | 1 | 6.53 |
| CHEMBL386843 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217511 | — | EC50 | = | 0.6761 | nM | 9.17 |
| CHEMBL215375 | — | EC50 | = | 19.05 | nM | 7.72 |
| CHEMBL11458 | — | EC50 | = | 21.88 | nM | 7.66 |
| CHEMBL214841 | — | EC50 | = | 28.84 | nM | 7.54 |
| CHEMBL11684 | (-)-CROMAKALIM | EC50 | = | 34.67 | nM | 7.46 |
| CHEMBL216256 | — | EC50 | = | 54.95 | nM | 7.26 |
| CHEMBL2062142 | — | EC50 | = | 102.33 | nM | 6.99 |
| CHEMBL424909 | — | EC50 | = | 128.82 | nM | 6.89 |
| CHEMBL387063 | — | EC50 | = | 245.47 | nM | 6.61 |
| CHEMBL18861 | ZD-6169 | EC50 | = | 295.12 | nM | 6.53 |
| CHEMBL386843 | — | EC50 | = | 331.13 | nM | 6.48 |