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Compound Detail

CHEMBL217511

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O=C1COCC2=C1C(c1ccc(F)c(Br)c1)C1=C(O)OCC1=N2

Basic Information

ChEMBL ID CHEMBL217511
Phase Preclinical
Structure Type MOL
InChI Key AGONOBBCSZYGHI-UHFFFAOYSA-N
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

380.2
MW (Da)
2.78
ALogP
5
HBA
1
HBD
68.1
PSA (Ų)
0.81
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H11BrFNO4
MW 380.17
Aromatic Rings 1
Heavy Atoms 23
NP-Likeness -0.39

Activity Summary

EC50 4 meas. best 9.17

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Sulfonylurea receptor 2, Kir6.2
CHEMBL2095198
EC50 9.17 7.6525 0.7 4

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17154517 10.1021/jm060549u Sulfonylurea receptor 2, Kir6.2 8

Data from ChEMBL 36 via Core Engine