Assay Detail
Functional
CHEMBL908370
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Intrinsic activity at adenosine A1 receptor assessed as blockade of CPA in isolated spontaneously beating rat atria
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 9.53 | 9.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216269 | — | — | 1 | 9.90 |
| CHEMBL414157 | TONAPOFYLLINE | 3.0 | 1 | 9.80 |
| CHEMBL450341 | — | — | 1 | 8.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216269 | — | Kd | = | 0.1259 | nM | 9.90 |
| CHEMBL414157 | TONAPOFYLLINE | Kd | = | 0.1585 | nM | 9.80 |
| CHEMBL450341 | — | Kd | = | 1.318 | nM | 8.88 |