Assay Detail
Functional
CHEMBL908409
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Antiviral activity against HIV1 3B in MT2 cells
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Optimization of pyrimidinyl- and triazinyl-amines as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 36 | 7.10 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.70 |
| CHEMBL384065 | — | — | 1 | 8.70 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.70 |
| CHEMBL218519 | — | — | 1 | 8.30 |
| CHEMBL385225 | — | — | 1 | 8.30 |
| CHEMBL221606 | — | — | 1 | 8.22 |
| CHEMBL374947 | — | — | 1 | 8.05 |
| CHEMBL372166 | — | — | 1 | 8.00 |
| CHEMBL221081 | — | — | 1 | 7.96 |
| CHEMBL375067 | — | — | 1 | 7.82 |
| CHEMBL217892 | — | — | 1 | 7.80 |
| CHEMBL201689 | — | — | 1 | 7.77 |
| CHEMBL381722 | — | — | 1 | 7.75 |
| CHEMBL218518 | — | — | 1 | 7.66 |
| CHEMBL218016 | — | — | 1 | 7.51 |
| CHEMBL375446 | — | — | 1 | 7.51 |
| CHEMBL202707 | — | — | 1 | 7.41 |
| CHEMBL218157 | — | — | 1 | 7.39 |
| CHEMBL201357 | — | — | 1 | 7.12 |
| CHEMBL217972 | — | — | 1 | 7.05 |
| CHEMBL218517 | — | — | 1 | 7.00 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.96 |
| CHEMBL217954 | — | — | 1 | 6.80 |
| CHEMBL202247 | — | — | 1 | 6.70 |
| CHEMBL201926 | — | — | 1 | 6.60 |
| CHEMBL374137 | — | — | 1 | 6.54 |
| CHEMBL414870 | — | — | 1 | 6.51 |
| CHEMBL218014 | — | — | 1 | 6.50 |
| CHEMBL384997 | — | — | 1 | 6.41 |
| CHEMBL221917 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL384065 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL218519 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL385225 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL221606 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL374947 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL372166 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL221081 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL375067 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL217892 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL201689 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL381722 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL218518 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL375446 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL218016 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL202707 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL218157 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL201357 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL217972 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL218517 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL217954 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL202247 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL201926 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL374137 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL414870 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL218014 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL384997 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL221917 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL218161 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL221079 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL382913 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL217905 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL218516 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL217970 | — | EC50 | = | 13000.0 | nM | 4.89 |