Assay Detail
Functional
CHEMBL908421
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IL4-induced proliferation of TF1 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TF-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.65 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL557844 | — | — | 1 | 7.70 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 7.10 |
| CHEMBL221912 | — | — | 1 | 7.05 |
| CHEMBL375205 | — | — | 1 | 6.77 |
| CHEMBL221976 | — | — | 1 | 6.47 |
| CHEMBL375296 | — | — | 1 | 6.43 |
| CHEMBL222027 | — | — | 1 | 6.40 |
| CHEMBL323994 | — | — | 1 | 6.22 |
| CHEMBL218746 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL557844 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL221912 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL375205 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL221976 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL375296 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL222027 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL323994 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL218746 | — | IC50 | = | 2010.0 | nM | 5.70 |