Assay Detail
Functional
CHEMBL908422
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Inhibition of IL3-induced proliferation of TF1 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TF-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.33 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL557844 | — | — | 1 | 7.52 |
| CHEMBL221912 | — | — | 1 | 6.36 |
| CHEMBL323994 | — | — | 1 | 6.30 |
| CHEMBL375296 | — | — | 1 | 6.24 |
| CHEMBL375205 | — | — | 1 | 6.22 |
| CHEMBL222027 | — | — | 1 | 6.21 |
| CHEMBL221976 | — | — | 1 | 6.20 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 6.10 |
| CHEMBL218746 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL557844 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL221912 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL323994 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL375296 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL375205 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL222027 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL221976 | — | IC50 | = | 635.0 | nM | 6.20 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL218746 | — | IC50 | = | 1400.0 | nM | 5.85 |