Assay Detail
Binding
CHEMBL908768
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Inhibition of [3H]methyl dThd phosphorylation by HSV1 TK
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human alphaherpesvirus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.97 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219299 | — | — | 1 | 6.16 |
| CHEMBL219960 | — | — | 1 | 6.00 |
| CHEMBL220459 | — | — | 1 | 5.70 |
| CHEMBL219458 | — | — | 1 | 5.57 |
| CHEMBL216998 | — | — | 1 | 5.43 |
| CHEMBL219905 | — | — | 1 | 4.77 |
| CHEMBL373997 | — | — | 1 | 4.75 |
| CHEMBL219510 | — | — | 1 | 4.68 |
| CHEMBL373998 | — | — | 1 | 4.60 |
| CHEMBL216997 | — | — | 1 | 4.50 |
| CHEMBL438603 | — | — | 1 | 4.39 |
| CHEMBL385954 | — | — | 1 | 4.38 |
| CHEMBL101135 | — | — | 1 | 4.35 |
| CHEMBL384435 | — | — | 1 | 4.34 |
| CHEMBL374244 | — | — | 1 | - |
| CHEMBL219367 | — | — | 1 | - |
| CHEMBL219908 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219299 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL219960 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL220459 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL219458 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL216998 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL219905 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL373997 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL219510 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL373998 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL216997 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL438603 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL385954 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL101135 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL384435 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL374244 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL219367 | — | IC50 | >= | 50000.0 | nM | - |
| CHEMBL219908 | — | IC50 | > | 500000.0 | nM | - |