Assay Detail
Functional
CHEMBL908797
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Inhibition of HCT116 cell proliferation (mean of two experiments)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.92 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217716 | — | — | 1 | 6.24 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217716 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2520.0 | nM | 5.60 |