Assay Detail
Functional
CHEMBL909291
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV1 in CBMCs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Natural polymorphisms in the human immunodeficiency virus type 2 protease can accelerate time to development of resistance to protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.75 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 8.70 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 7.85 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 7.58 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 7.57 |
| CHEMBL222559 | TIPRANAVIR | 4.0 | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL729 | LOPINAVIR | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL584 | NELFINAVIR | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL116 | AMPRENAVIR | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5483011 | INDINAVIR | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL222559 | TIPRANAVIR | IC50 | = | 92.0 | nM | 7.04 |